Xylazine hydrochloride( —— )

Catalog No. M13646 CAS No. 23076-35-9

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Product Name

Xylazine hydrochloride
Note

Research use only, not for human use.
Brief Description

Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.
Description

Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.(In Vivo):Xylazine (5.2 mg/kg; intraperitoneal injection; for 10-60 minutes; male Sprague-Dawley rats) administration alters mRNA expression and protein phosphorylation levels of AMPK signaling molecules, suggesting that the LKB1-AMPK pathway plays a role in the sedative and tranquilizing effects in the CNS caused by Xylazine treatment.
In Vitro

——
In Vivo

Xylazine (5.2 mg/kg; intraperitoneal injection; for 10-60 minutes; male Sprague-Dawley rats) administration alters mRNA expression and protein phosphorylation levels of AMPK signaling molecules, suggesting that the LKB1-AMPK pathway plays a role in the sedative and tranquilizing effects in the CNS caused by Xylazine treatment. Animal Model:Male Sprague-Dawley rats (160-180 g)Dosage:5.2 mg/kg Administration:Intraperitoneal injection; for 10 minutes, 20 minutes, 40 minutesor 60 minutes Result:Increased in AMPK activity in the cerebral cortex, hippocampus, thalamus and cerebellum. Phosphorylated LKB1 and AMPKα protein levels were decreased.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

Adrenergic Receptor
Recptor

α-adrenergic receptor
Research Area

Neurological Disease
Indication

——

CAS Number

23076-35-9
Formula Weight

256.79
Molecular Formula

C12H16N2S·HCl
Purity

>98% (HPLC)
Solubility

Ethanol: 50 mg/mL (194.71 mM); Water: 12 mg/mL (46.73 mM); DMSO: 50 mg/mL (194.71 mM)
SMILES

Cl.CC1=CC=CC(C)=C1NC1=NCCCS1
Chemical Name

——

1.Ambrisko TD, et al. Can J Vet Res,2002, 66(1), 42-49.

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